Studied mechanism
NNMT (nicotinamide N-methyltransferase) is an enzyme whose expression increases in adipose tissue in the context of obesity across several preclinical models. 5-Amino-1MQ is studied as a selective inhibitor of this enzyme, with research interest focused on its influence on the regulation of cellular energy metabolism and NAD+ levels.
Level of evidence
Available publications on 5-Amino-1MQ are mainly based on preclinical models (cellular and animal). It is a relatively recent compound in the metabolic research literature, with no published human clinical trial to date.
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